Users Guide:Digitizer and readout parameters
- 1 General Purpose
- 2 Digitizer modules
- 2.1 Distributions
- 2.2 Adder
- 2.3 Adder Compton
- 2.4 Readout
- 2.5 Blurring : Energy blurring
- 2.6 Blurring : crystal blurring
- 2.7 Blurring : Local energy blurring for different crystals
- 2.8 Blurring: Intrinsic resolution blurring with crystals of different compositions
- 2.9 Calibration
- 2.10 Crosstalk
- 2.11 Thresholder & Upholder
- 2.12 Energy windows
- 2.13 Sigmoidal thresholder
- 2.14 Time resolution
- 2.15 Spatial blurring
- 2.16 Noise
- 2.17 Local efficiency
- 2.18 Memory buffers and bandwidth
- 2.19 Pile-up
- 2.20 Dead time
- 3 Multiple processor chains
- 4 Coincidence sorter
- 5 Multiple coincidence sorters
- 6 Coincidence processing and filtering
- 7 Example of a digitizer setting
- 8 Digitizer optimization
- 9 Angular Response Functions to speed-up planar or SPECT simulations
- 10 Multi-system approaches: how to use more than one system in one simuation set-up ?
The purpose of the digitizer module is to simulate the behaviour of the scanner detectors and signal processing chain.
From particle detection to coincidences in GATE
GATE uses Geant4 to generate particles and transport them through the materials. This mimics physical interactions between particles and matter. The information generated during this process is used by GATE to simulate the detector pulses (digits), which correspond to the observed data. The digitizer represents the series of steps and filters that make up this process.
The typical data-flow for an event is as follows:
- A particle is generated, with its parameters, such as initial type, time, momentum, and energy.
- An elementary trajectory step is applied. A step corresponds to the trajectory of a particle between discrete interactions (i.e. photoelectric, Compton, pair production, etc). During a step, the changes to particle's energy and momentum are calculated. The length of a step depends upon the nature of the interaction, the type of particle and material, etc. The calculation of the step length is complex and is mentioned here only briefly. For more details, please refer to the Geant4 documentation.
- If a step occurs within a volume corresponding to a sensitive detector, the interaction information between the particle and the material is stored. For example, this information may include the deposited energy, the momentum before and after the interaction, the name of the volume where the interaction occurred, etc. This set of information is referred to as a Hit.
- Steps 2 and 3 are repeated until the energy of the particle becomes lower than a predefined value, or the particle position goes outside the predefined limits. The entire series of steps form a simulated trajectory of a particle, that is called a Track in Geant4.
- The amount of energy deposited in a crystal is filtered by the digitizer module. The output from the digitizer corresponds to the signal after it has been processed by the Front End Electronics (FEE). Generally, the FEE is made of several processing units, working in a serial and/or in parallel. This process of transforming the energy of a Hit into the final digital value is called Digitization and is performed by the GATE digitizer. Each processing unit in the FEE is represented in GATE by a corresponding digitizer module. The final value obtained after filtering by a set of these modules is called a Single. Singles can be saved as output. Each transient value, between two modules, is called a Pulse.
This process is repeated for each event in the simulation in order to produce one or more sets of Singles. These Singles can be stored into an output file (as a ROOT tree, for example).
In case of PET systems, a second processing stage can be inserted to sort the Singles list for coincidences. To do this, the algorithm searches in this list for a set of Singles that are detected within a given time interval (the so called 'coincident events').
Finally, the coincidence data may be filtered-out to mimic any possible data loss which could occur in the coincidence logical circuit or during the data transportation. As for the Singles, the processing is performed by specifying a list of generic modules to apply to the coincidence data flow.
Definition of a hit in Geant4
A hit is a snapshot of the physical interaction of a track within a sensitive region of a detector. The information given by a hit is
- Position and time of the step
- Momentum and energy of the track
- Energy deposition of the step
- Interaction type of the hit
- Volume name containing the hit
As a result, the history of a particle is saved as a series of hits generated along the particles trajectory. In addition to the physical hits, Geant4 saves a special hit. This hit takes place when a particle moves from one volume to another (this type of hit deposits zero energy). The hit data represents the basic information that a user has with which to construct the physically observable behaviour of a scanner. To see the information stored in a hit, see the file GateCrystalHit.hh.
Role of the digitizer
As mentioned above, the information contained in the hit does not correspond to what is provided by a real detector. To simulate the digital values ( pulses) that result from the output of the Front End Electronics, the sampling methods of the signal must be specified. To do this, a number of digitizer modules are available and are described below.
The role of the digitizer is to build, from the hit information, the physical observables, which include energy, position, and time of detection for each particle. In addition, the digitizer must implement the required logic to simulate coincidences during PET simulations. Typical usage of digitizer module includes the following actions:
- simulate detector response
- simulate readout scheme
- simulate trigger logic
These actions are accomplished by inserting digitizer modules into GATE, as explained in the next sections.
Disabling the digitizer
If you want to disable the digitizer process and all output (that are already disabled by default), you can use the following commands:
The digitization consists of a series of signal processors. The output at each step along the series is defined as a pulse. At the end of the chain, the output pulses are named singles. These Singles realistically simulate the physical observables of a detector response to a particle interacting with it. An example is shown in figure 8.1.
To specify a new signal-processing module (i.e. add a new processing unit in the readout scheme) the following command template should be used :
where MODULE is the name of the digitizer module. The order of the module declaration should make sense. The data flow follows the same order as the module declaration in the macro. In a typical scanner, the following sequence works well, athough it is not mandatory (the module names will be explained in the rest of the section):
- insert adder before readout
- insert readout before thresholder/upholder
- insert blurring before thresholder/upholder
Since many of the modules presented below have to deal with functions or probability density, a generic tool is provided to describe such mathematical objects in GATE. Basically, a distribution in GATE is defined by its name, its type (Gaussian, Exponential, etc...) and the parameters specifics to each distribution type (such as the mean and the standard deviation of a Gaussian function). Depending on the context, these objects are used directly as functions, or as probability densities into which a variable is randomly chosen. In the following, the generic term of distribution will be used to describe both of these objects, since their declaration is unified under this term into GATE.
Five types of distribution are available in GATE, namely:
- Flat distributions, defined by the range into which the function is not null, and the value taken within this range.
- Gaussian distributions, defined by a mean value and a standard deviation.
- Exponential distributions, defined by its power.
- Manual distributions, defined by a discrete set of points specified in the GATE macro file. The data are linearly interpolated to define the function in a continuous range.
- File distribution, acting as the manual distribution, but where the points are defined in a separate ASCII file, whose name is given as a parameter. This method is appropriate for large numbers of points and allows to describe any distribution in a totally generic way.
A distribution is declared by specifying its name then by creating a new instance, with its type name:
/gate/distributions/name my_distrib /gate/distributions/insert Gaussian
The possible type name available corresponds to the five distributions described above, that is Flat, Gaussian, Exponential, Manual or File. Once the distribution is created (for example a Gaussian), the related parameters can be set:
/gate/distributions/my_distrib/setMean 350 keV /gate/distributions/my_distrib/setSigma 30 keV
|setMin||set the low edge of the range where the function is not null (default is 0)|
|SetMax||set the high edge of the range where the function is not null (default is 1)|
|setAmplitude||set the value taken by the function within the non null range (default is 1)|
|setMean||set the mean value of the distribution (default is 0)|
|setSigma||set the standard deviation of the distribution (default is 1).|
|setAmplitude||set the amplitude of the distribution (default is 1).|
|setLambda||set the power of the distribution (default is 1).|
|setAmplitude||set the amplitude of the distribution (default is 1).|
|setUnitX||set the unit for the x axis.|
|setUnitY||set the unit for the y axis.|
|insertPoint||insert a new point, giving a pair of (x,y) values.|
|addPoint||add a new point, giving its y value, and auto incrementing the x value.|
|autoXstart||in case of auto incremental x value, set the first x value to use.|
|setUnitX||set the unit for the x axis.|
|setUnitY||set the unit for the y axis.|
|autoX||specify if the x values are read from file or if they are auto-incremented.|
|autoXstart||in case of auto incremental x value, set the first x value to use.|
|setFileName||the name of the ASCII file where the data have to be read.|
|setColumnX||which column of the ASCII file contains the x axis data.|
|setColumnY||which column of the ASCII file contains the y axis data.|
|read||do read the file (should be called after specifying all the other parameters).|
One particle often creates multiple interactions, and consequently multiple hits, within a crystal. The first step of the digitizer is to sum all the hits that occur within the same crystal (i.e. the same volume). This is due to the fact that the electronics always measure an integrated signal, and do not have the time or energy resolution necessary to distinguish between the individual interactions of the particle within a crystal. This digitizer action is completed by a module called the adder. The adder should be the first module of a digitizer chain. It acts on the lowest level in the system hierarchy, as explained in Users Guide:Defining a system :
- A system must be used to describe the geometry (also the mother volume name must corresponds to a system name)
- The lowest level of this system must be attached to the detector volume and must be declared as a sensitive detector
The adder regroups hits per volume into a pulse. If one particle that enters a detector makes multiple hits within two different crystal volumes before being stopped, the output of the adder module will consists of two pulses. Each pulse is computed as follows : the energy is taken to be the total of energies in each volume, the position is obtained with an energy-weighted centroid of the different hit positions. The time is equal to the time at which the first hit occured.
The command to use the adder module is
The adderCompton module has a different behavior than the classic adder, which performs an energy-weighted centroid addition of all electronic and photonic hits. Instead, for each electronic energy deposition, the energy is added to the previous photonic hit in the same volume ID (or discarded if none), but the localization remains that of the photonic interaction. That way, the Compton kinematics becomes exact for photonic interations, enabling further studies. The user must use the classic adder afterwards, to handle multiple photonic interactions in the same crystal. The commands to use the adder module are
/gate/digitizer/Singles/insert adderCompton /gate/digitizer/Singles/insert adder
With the exception of a detector system where each crystal is read by an individual photo-detector, the readout segmentation is often different from the basic geometrical structures of the detector. The readout geometry is an artificial geometry that is usually associated with a group of sensitive detectors. There are two ways of modelling this readout process : either a winner-takes-all approach that will somewhat model APD-like readout, or a energy-centroid approach that will be closer to the block-PMT readout. Using the winner-takes-all policy, the grouping has to be determined by the user through a variable named depth corresponding to the component in the volume hierarchy at which pulses are summed together. Using this variable, the pulses are summed if their volume ID's are identical to this level of depth. Using the energy-centroid policy, the depth of the grouping is forced to occur at the 'crystal' level whatever the system used, so the depth variable is ignored. This means that the pulses in a same level just above the crystal level are summed together.
The readout module regroups pulses per block (group of sensitive detectors). For both policy, the resulting pulse in the block has the total energy of all pulses summed together. For the winner-takes-all policy, the position of the pulse is the one with the maximum energy. For the energy-centroid policy, the position is determined by weighting the crystal indices of each pulse by the deposited energy in order to get the energy centroid position. In this case, only the crystal index is determined, and the actual cartesian coordinates of the resulting pulse are reset to the center of this crystal. If a sub-level of the crystal is used (different layers), then the final sub-level is determined by the one having the maximum energy deposited (so a winner-takes-all approach for these sub-levels of the crystal is used).
/gate/digitizer/Singles/insert readout /gate/digitizer/Singles/readout/setPolicy myPolicy /gate/digitizer/Singles/readout/setDepth X
The parameter myPolicy can be TakeEnergyWinner for the winner-takes-all policy or TakeEnergyCentroid for the energy centroid policy. If the energy centroid policy is used, the depth is forced to be at the level just above the crystal level, whatever the system used. If the winner-takes-all policy is used, then the user must choose the depth at which the readout process takes place. If the setPolicy command is not set, then the winner-takes-all policy is chosen by default in order to be back-compatible with previous Gate releases.
Figure 8.2 illustrates the actions of both the adder and readout modules. The adder module transforms the hits into a pulse in each individual volume and then the readout module sums a group of these pulses into a single pulse at the level of depth as defined by the user for the winner-takes-all policy.
The importance of the setDepth command line when using the winner-takes-all policy is illustrated through the following example from a PET system (see Users Guide:Defining a system). In a cylindricalPET system, where the first volume level is rsector, and the second volume level is module, as shown in figure 8.3, the readout depth depends upon how the electronic readout functions.
If one PMT reads the four modules in the axial direction, the depth should be set with the command:
The energy of this single event is the sum of the energy of the pulses inside the white rectangle (rsector) of figure 8.3. However, if individual PMTs read each module (group of crystals), the depth should be set with the command:
In this case, the energy of the single event is the sum of the energies of the pulses inside the red box (module) of figure 8.3.
The next task is to transform this output pulse from the readout module into a single which is the physical observable of the experiment. This transformation is the result of the detector response and should mimic the behaviors of the photo-detector, electronics, and acquisition system.
Blurring : Energy blurring
The blurring pulse-processor module simulates Gaussian blurring of the energy spectrum of a pulse after the readout module. This is accomplished by introducing a resolution, (FWHM), at a given energy, . According to the camera, the energy resolution may follow different laws, such as an inverse square law or a linear law.
For inverse square law (), one must specify the inverse square law and fix the attributes like the energy of reference and the resolution (example of a 15% resolution @ 511 KeV):
/gate/digitizer/Singles/blurring /gate/digitizer/Singles/blurring/setLaw inverseSquare /gate/digitizer/Singles/blurring/inverseSquare/setResolution 0.15 /gate/digitizer/Singles/blurring/inverseSquare/setEnergyOfReference 511. keV
For linear law, one must specify the linear law and fix the attributes like the energy of reference, the resolution and the slope:
/gate/digitizer/Singles/blurring /gate/digitizer/Singles/blurring/setLaw linear /gate/digitizer/Singles/blurring/linear/setResolution 0.15 /gate/digitizer/Singles/blurring/linear/setEnergyOfReference 511. keV /gate/digitizer/Singles/blurring/linear/setSlope -0.055 1/MeV
Blurring : crystal blurring
This type of blurring is used for the scanners where all the detectors are made of the same type of crystal. In this case, it is often useful to assign a different energy resolution for each crystal in the detector block, between a minimum and a maximum value. To model the efficiency of the system, a coefficient (between 0 and 1) can also be set.
As an example, a random blurring of all the crystals between 15% and 35% at a reference energy of 511 keV, and with a quantum efficiency of 90% can be modelled using the following commands:
/gate/digitizer/Singles/insert crystalblurring /gate/digitizer/Singles/crystalblurring/setCrystalResolutionMin 0.15 /gate/digitizer/Singles/crystalblurring/setCrystalResolutionMax 0.35 /gate/digitizer/Singles/crystalblurring/setCrystalQE 0.9 /gate/digitizer/Singles/crystalblurring/setCrystalEnergyOfReference 511.keV
In this example, for each interaction the program randomly chooses a crystal resolution between 0.15 and 0.35. The crystals are not assigned a constant resolution. The crystal quantum efficiency is set using setCrystalQE and represents the probability for the event to be detected by the photo-detector. This parameter represents the effect of the transfer efficiency of the crystal and of the quantum efficiency of the photo-detector.
Blurring : Local energy blurring for different crystals
The LocalBlurring module is very similar to the energy blurring module, but different energy resolutions are applied to different volumes. This type of blurring is useful for detectors with several layers of different scintillation crystals (e.g. depth of interaction measurement with a phoswich module in a CylindricalPET system).
If a detector has a resolution of 15.3% @ 511 KeV for a crystal called crystal1 and has a resolution of 24.7% @ 511 KeV for another crystal (crystal2) in a phoswich configuration, the following commands should be used:
/gate/digitizer/Singles/insert localBlurring /gate/digitizer/Singles/localBlurring/chooseNewVolume crystal1 /gate/digitizer/Singles/localBlurring/crystal1/setResolution 0.153 /gate/digitizer/Singles/localBlurring/crystal1/setEnergyOfReference 511 keV /gate/digitizer/Singles/localBlurring/chooseNewVolume crystal2 /gate/digitizer/Singles/localBlurring/crystal2/setResolution 0.247 /gate/digitizer/Singles/localBlurring/crystal2/setEnergyOfReference 511 keV
BEWARE: crystal1 and crystal2 must be valid Sensitive Detector volume names !!
Blurring: Intrinsic resolution blurring with crystals of different compositions
This blurring pulse-processor simulates a local Gaussian blurring of the energy spectrum (different for different crystals) based on the following model:
where and , and , are the Light Yield, Transfer, and Quantum Efficiency for each crystal.
is the relative variance of the gain of a Photo Multiplier Tube (PMT) or of an Avalanche Photo Diode (APD). It is hard-codded and set to 0.1.
If the intrinsic resolutions, , of the individual crystals are not defined, then they are set to one.
To use this digitizer module properly, several modules must be set first. These digitizer modules are GateLightYield, GateTransferEfficiency, and GateQuantumEfficiency. The light yield pulse-processor simulates the crystal light yield. Each crystal must be given the correct light yield. This module converts the pulse energy into the number of scintillation photons emitted, . The transfer efficiency pulse-processor simulates the transfer efficiencies of the light photons in each crystal. This digitizer reduces the "pulse" energy (by reducing the number of scintillation photons) by a transfer efficiency coefficient which must be a number between 0 and 1. The quantum efficiency pulse-processor simulates the quantum efficiency for each channel of a photo-detector, which can be a Photo Multiplier Tube (PMT) or an Avalanche Photo Diode (APD).
The command lines are illustrated using an example of a phoswich module made of two layers of different crystals. One crystal has a light yield of 27000 photons per MeV (LSO crystal), a transfer efficiency of 28%, and an intrinsic resolution of 8.8%. The other crystal has a light yield of 8500 photons per MeV (LuYAP crystal), a transfer efficiency of 24% and an intrinsic resolution of 5.3%
In the case of a cylindricalPET system, the construction of the crystal geometry is truncated for clarity (the truncation is denoted by ...). The digitizer command lines are:
# LSO layer /gate/crystal/daughters/name LSOlayer .... # BGO layer /gate/crystal/daughters/name LuYAPlayer .... # A T T A C H S Y S T E M .... /gate/systems/cylindricalPET/crystal/attach crystal /gate/systems/cylindricalPET/layer0/attach LSOlayer /gate/systems/cylindricalPET/layer1/attach LuYAPlayer # A T T A C H C R Y S T A L S D /gate/LSOlayer/attachCrystalSD /gate/LuYAPlayer/attachCrystalSD # In this example the phoswich module is represented by the crystal volume and is made of two different material layers. # To apply the resolution blurring of equation , the parameters discussed above must be defined for each layer #(i.e. Light Yield, Transfer, Intrinsic Resolution, and the Quantum Efficiency). # DEFINE TRANSFER EFFICIENCY FOR EACH LAYER /gate/digitizer/Singles/insert transferEfficiency /gate/digitizer/Singles/transferEfficiency/chooseNewVolume LSOlayer /gate/digitizer/Singles/transferEfficiency/LSOlayer/setTECoef 0.28 /gate/digitizer/Singles/transferEfficiency/chooseNewVolume LuYAPlayer /gate/digitizer/Singles/transferEfficiency/LuYAPlayer/setTECoef 0.24 # DEFINE LIGHT YIELD FOR EACH LAYER /gate/digitizer/Singles/insert lightYield /gate/digitizer/Singles/lightYield/chooseNewVolume LSOlayer /gate/digitizer/Singles/lightYield/LSOlayer/setLightOutput 27000 /gate/digitizer/Singles/lightYield/chooseNewVolume LuYAPlayer /gate/digitizer/Singles/lightYield/LuYAPlayer/setLightOutput 8500 # DEFINE INTRINSIC RESOLUTION FOR EACH LAYER /gate/digitizer/Singles/insert intrinsicResolutionBlurring /gate/digitizer/Singles/intrinsicResolutionBlurring/ chooseNewVolume LSOlayer /gate/digitizer/Singles/intrinsicResolutionBlurring/ LSOlayer/setIntrinsicResolution 0.088 /gate/digitizer/Singles/intrinsicResolutionBlurring/ LSOlayer/setEnergyOfReference 511 keV /gate/digitizer/Singles/intrinsicResolutionBlurring/ chooseNewVolume LuYAPlayer /gate/digitizer/Singles/intrinsicResolutionBlurring/ LuYAPlayer/setIntrinsicResolution 0.053 /gate/digitizer/Singles/intrinsicResolutionBlurring/ LuYAPlayer/setEnergyOfReference 511 keV # DEFINE QUANTUM EFFICIENCY OF THE PHOTODETECTOR /gate/digitizer/Singles/insert quantumEfficiency /gate/digitizer/Singles/quantumEfficiency/chooseQEVolume crystal /gate/digitizer/Singles/quantumEfficiency/setUniqueQE 0.1
Note: A complete example of a phoswich module can be in the PET benchmark.
Note for Quantum Efficiency
With the previous commands, the same quantum efficiency will be applied to all the detector channels. The user can also provide lookup tables for each detector module. These lookup tables are built from the user files.
To set multiple quantum efficiencies using files (fileName1, fileName2, ... for each of the different modules), the following commands can be used:
/gate/digitizer/Singles/insert quantumEfficiency /gate/digitizer/Singles/quantumEfficiency/chooseQEVolume crystal /gate/digitizer/Singles/quantumEfficiency/useFileDataForQE fileName1 /gate/digitizer/Singles/quantumEfficiency/useFileDataForQE fileName2
If the crystal volume is a daughter of a module volume which is an array of 8 x 8 crystals, the file fileName1 will contain 64 values of quantum efficiency. If several files are given (in this example two files), the program will choose randomly between theses files for each module.
After the introduction of the lightYield (LY), transferEfficiency and quantumEfficiency} modules, the energy variable of a pulse is not in energy unit (MeV) but in number of photoelectrons .
In order to correctly apply a threshold on a phoswhich module, the threshold should be based on this number and not on the real energy. In this situation, to apply a threshold at this step of the digitizer chain, the threshold should be applied as explained in #Thresholder & Upholder. In this case, the GATE program knows that these modules have been used, and will apply threshold based upon the number rather than energy. The threshold set with this sigmoidal function in energy unit by the user is translated into number with the lower light yield of the phoswish module. To retrieve the energy it is necessary to apply a calibration module.
The Calibration module of the pulse-processor models a calibration between and . This is useful when using the class(es) GateLightYield, GateTransferEfficiency, and GateQuantumEfficiency. In addition, a user specified calibration factor can be used. To set a calibration factor on the energy, use the following commands:
/gate/digitizer/Singles/insert calibration /gate/digitizer/Singles/setCalibration VALUE
If the calibration digitizer is used without any value, it will correct the energy as a function of values used in GateLightYield, GateTransferEfficiency, and GateQuantumEfficiency.
The crosstalk module simulates the optical and/or electronic crosstalk of the scintillation light between neighboring crystals. Thus, if the input pulse arrives in a crystal array, this module creates pulses around it (in the edge and corner neighbor crystals). The percentage of energy that is given to the neighboring crystals is determined by the user. To insert a crosstalk module that distributes 10% of input pulse energy to the adjacent crystals and 5% to the corner crystals, the following commands can be used:
/gate/digitizer/Singles/insert crosstalk /gate/digitizer/Singles/crosstalk/chooseCrosstalkVolume crystal /gate/digitizer/Singles/crosstalk/setEdgesFraction 0.1 /gate/digitizer/Singles/crosstalk/setCornersFraction 0.05
In this example, a pulse is created in each neighbor of the crystal that received the initial pulse. These secondary pulses have 10% (5% for each corner crystals) of the initial energy of the pulse.
BEWARE: this module works only for a chosen volume that is an array repeater!!!
Thresholder & Upholder
The Thresholder/Upholder modules allow the user to apply an energy window to discard low and high energy photons. The low energy cut, supplied by the user, represents a threshold response, below which the detector remains inactive. The user-supplied high energy cut is the maximum energy the detector will register. In both PET and SPECT analysis, the proper setting of these windows is crucial to mimic the behavior of real scanners, in terms of scatter fractions and count rate performances for instance. In a typical PET scanner, the energy selection for the photo-peak is performed using the following commands. A low threshold of 0 keV allows the user to see all the events, and is often useful for debugging a simulation.
/gate/digitizer/Singles/insert thresholder /gate/digitizer/Singles/thresholder/setThreshold 250. keV /gate/digitizer/Singles/insert upholder /gate/digitizer/Singles/upholder/setUphold 750. keV
In SPECT analysis, subtractive scatter correction methods such as the dual-energy-window or the triple-energy-window method may be performed in post processing on images obtained from several energy windows. If one needs multiple energy windows, several digitizer branches will be created. Furthermore, the projections associated to each energy window can be recorded into one interfile output. In the following example, 3 energy windows are defined separately with their names and thresholds (see #Thresholder & Upholder):
/gate/digitizer/name Window1 /gate/digitizer/insert singleChain /gate/digitizer/Window1/setInputName Singles /gate/digitizer/Window1/insert thresholder /gate/digitizer/Window1/thresholder/setThreshold 315 keV /gate/digitizer/Window1/insert upholder /gate/digitizer/Window1/upholder/setUphold 328 keV /gate/digitizer/name Window2 /gate/digitizer/insert singleChain /gate/digitizer/Window2/setInputName Singles /gate/digitizer/Window2/insert thresholder /gate/digitizer/Window2/thresholder/setThreshold 328 keV /gate/digitizer/Window2/insert upholder /gate/digitizer/Window2/upholder/setUphold 400 keV /gate/digitizer/name Window3 /gate/digitizer/insert singleChain /gate/digitizer/Window3/setInputName Singles /gate/digitizer/Window3/insert thresholder /gate/digitizer/Window3/thresholder/setThreshold 400 keV /gate/digitizer/Window3/insert upholder /gate/digitizer/Window3/upholder/setUphold 416 keV
When specifying the interfile output (see Users Guide:Data output#Interfile output of projection set), the different window names must be added with the following commands :
/gate/output/projection/setInputDataName Window1 /gate/output/projection/addInputDataName Window2 /gate/output/projection/addInputDataName Window3
The Sigmoidal thresholder models a threshold discriminator based on a sigmoidal function. A sigmoidal function is an S-shaped function of the form, , which acts as an exponential ramp from 0 to 1:
where the parameter is proportional to the slope at symmetrical point .
For this type of threshold discriminator, the user chooses the threshold setThreshold, the percentage of acceptance for this threshold setThresholdPerCent, and the parameter setThresholdAlpha. With these parameters and the input pulse energy, the function is calculated. If the result is bigger than a random number generated between 0 and 1, the pulse is accepted and copied into the output pulse-list. On the other hand, if this criteria is not met, the input pulse is discarded.
/gate/digitizer/Singles/insert sigmoidalThresholder /gate/digitizer/Singles/sigmoidalThresholder/setThreshold 250 keV /gate/digitizer/Singles/sigmoidalThresholder/setThresholdAlpha 60. /gate/digitizer/Singles/sigmoidalThresholder/setThresholdPerCent 0.95
The temporal resolution module introduces a Gaussian blurring in the time domain. It works in the same manner as the blurring module, but with time instead of energy. To set a Gaussian temporal resolution (FWHM) of 1.4 ns, use the following commands:
/gate/digitizer/Singles/insert timeResolution /gate/digitizer/Singles/timeResolution/setTimeResolution 1.4 ns
For SPECT simulations, the spatial resolution is assumed to follow a Gaussian distribution defined by its width .
/gate/digitizer/Singles/insert spblurring /gate/digitizer/Singles/spblurring/setSpresolution 2.0 mm /gate/digitizer/Singles/spblurring/verbose 1
In PET analysis, coincidence events provide the lines of response (LOR) needed for the image reconstruction. Only the two crystal numbers are transferred by the simulation. The determination of these crystal numbers is based on the crystal in which the highest energy has been deposited. Without additional spatial blurring of the crystal, simulation results will always have a better spatial resolution than experimental measurements. This module is only available for the ecat system. The spatial blurring is based on a 2D Gaussian function.
# E C A T 7 /gate/output/sinogram/enable /gate/output/sinogram/RadialBins Your_Sinogram_Radial_Bin_Number /gate/output/sinogram/setTangCrystalBlurring Your_Value_1 mm /gate/output/sinogram/setAxialCrystalBlurring Your_Value_2 mm
Different sources of background noise exist in a PET/SPECT architecture. For example, the electronics can introduce its own noise, or some crystals used for the detection, such as LSO, contains radioactive nucleus, which can contribute to the background detection count rate. Within GATE, the noise module adds such background events, in a totally generic way, so that any kind of source of noise can be simulated. To do so, the energy and the inter-event time interval are chosen randomly, for each event, into user defined distributions, by using the mechanism described in #Distributions.
In the following example, a noise source is introduced, whose energy is distributed according to a Gaussian law, and whose time distribution follows a Poisson process. To do this, one first defines the two necessary distributions. Since the noise description uses the distribution of the time interval between consecutive events, one has to define an exponential distribution. Indeed, if the probability of detecting k events in a time interval of t is distributed along a Poisson law , then the probability density of having a time interval in the range between two consecutive events is given by .
/gate/distributions/name energy_distrib /gate/distributions/insert Gaussian /gate/distributions/energy_distrib/setMean 450 keV /gate/distributions/energy_distrib/setSigma 1 keV /gate/distributions/name dt_distrib /gate/distributions/insert Exponential /gate/distributions/dt_distrib/setLambda 7.57 mus /gate/digitizer/Singles/insert noise /gate/digitizer/Singles/noise/setDeltaTDistribution dt_distrib /gate/digitizer/Singles/noise/setEnergyDistribution energy_distrib
The special event ID, event_ID=-2, is assigned to these noise events.
The different crystals, or groups of crystals, composing a PET/SPECT system can be characterized by their own efficiency. GATE offers a method to describe such efficiency per crystal or volume. To define the efficiency distribution in the scanner, one can specify which level of the volume hierarchy of the system are differentiated (see the examples in #Command lines). Then the distribution of efficiency, for each differentiated volume, is specified via a generic distribution, as described in #Distributions.
In the following examples, one assumes that the system is composed of 8 blocks (level1) of 64 crystals (level2). The first example shows how to specify one efficiency per block, defined in a file named eff_per_block.dat, containing 8 values (one per block).
/gate/distributions/name block_eff_distrib /gate/distributions/insert File /gate/distributions/block_eff_distrib/autoX true /gate/distributions/block_eff_distrib/setFileName eff_per_block.dat /gate/distributions/block_eff_distrib/read /gate/digitizer/Singles/insert localEfficiency /gate/digitizer/Singles/localEfficiency/enableLevel 1 /gate/digitizer/Singles/localEfficiency/disableLevel 2 /gate/digitizer/Singles/localEfficiency/setEfficiency block_eff_distrib
In the second example, one specifies a different efficiency for each crystal inside a block, but the scheme is repeated from one block to another. So a pattern of 64 efficiency values is defined in the file eff_within_block.dat.
/gate/distributions/name within_block_eff_distrib /gate/distributions/insert File /gate/distributions/within_block_eff_distrib/autoX true /gate/distributions/within_block_eff_distrib/setFileName eff_within_block.dat /gate/distributions/within_block_eff_distrib/read /gate/digitizer/Singles/insert localEfficiency /gate/digitizer/Singles/localEfficiency/disableLevel 1 /gate/digitizer/Singles/localEfficiency/enableLevel 2 /gate/digitizer/Singles/localEfficiency/setEfficiency within_block_eff_distrib
Finally, in the next example, each crystal has its own efficiency, described in the file eff_per_crystal.dat containing 8 x 64 elements.
/gate/distributions/name crystal_eff_distrib /gate/distributions/insert File /gate/distributions/crystal_eff_distrib/autoX true /gate/distributions/crystal_eff_distrib/setFileName eff_per_crystal.dat /gate/distributions/crystal_eff_distrib/read /gate/digitizer/Singles/insert localEfficiency /gate/digitizer/Singles/localEfficiency/enableLevel 1 /gate/digitizer/Singles/localEfficiency/enableLevel 2 /gate/digitizer/Singles/localEfficiency/setEfficiency crystal_eff_distrib
Memory buffers and bandwidth
To mimic the effect of limited transfer rate, a module models the data loss due to an overflow of a memory buffer, read periodically, following a given reading frequency. This module uses two parameters, the reading frequency and the memory depth . Moreover, two reading methods can be modelled, that is, in an event per event basis (an event is read at each reading clock tick), or in a full buffer reading basic (at each reading clock tick, the whole buffer is emptied out). In the first reading method, the data rate is then limited to , while in the second method, the data rate is limited to . When the size limit is reached, any new pulse is rejected, until the next reading clock tick arrival which frees a part of the buffer. In such a case, a non null buffer depth allows to manage a local rise of the input data flow. To specify a buffer, read at 10 MHz, with a buffer depth of 64 events, in a mode where the whole buffer is read in one clock tick, one can use:
/gate/digitizer/Your_Single_chain/insert buffer /gate/digitizer/Your_Single_chain/buffer/setBufferSize 64 B /gate/digitizer/Your_Single_chain/buffer/setReadFrequency 10 MHz /gate/digitizer/Your_Single_chain/buffer/setMode 1
The chain Your_Single_chain can be the default chain Singles or any of single chain that the user has defined. The size of the buffer represents the number of elements, 64 Singles in this example, that the user can store in a buffer. To read the buffer in an event by event basis, one should replace the last line by setMode = 0.
An important characteristic of a detector is its response time, which is the time that the detector takes to form the signal after the arrival of the radiation. The duration of the signal is also important. During this period, if a second event can be accepted, this second signal will pile up on the first. The resulting pulse is a combinaison in terms of time and energy, of the two signals. If N pulses enter in the time window of the same sensitive volume (set by the depth of the system level), the output pulse of the pile-up module will be a pulse with an output energy defined by the sum of the energies and a time set to the last time of the last pulse participating to the pile-up . Since multiple events are grouped into a unique event with the pile-up effect, one can consider this as a loss of events occuring during a given time length, which can be seen as a dead time effect. Moreover, since the pile-up end time is always updated with the last single occuring, the effect is more or less represented by a paralysable dead-time. To insert a pile-up corresponding to a signal formation time of 100 ns in a module corresponding to the crystal group as described by the 4th level of the system, one should use:
/gate/digitizer/Singles/insert pileup /gate/digitizer/Singles/pileup/setDepth 4 /gate/digitizer/Singles/pileup/setPileup 100 ns
Due to the shaping time of signals or for any other reason, each detection of a single event can hide the subsequent single detected on the same electronic module. This loss lasts a certain amount of time, depending on the characteristics of the detectors used as well as of the readout electronics. The dead time can be modelled in GATE as shown below. Two models of the dead-time have been implemented in the digitizer: paralysable and nonparalysable response. These models can be implemented event by event during a simulation. The detailed method underlying these models can be found in Knoll 1979 (Radiation detection and measurement, John Wiley & Sons, New York). The fundamental assumptions made by these two models are illustrated in figure 8.4.
The dead time module is applied to a specific volume within the Sensitive Detector system hierarchy. All events taking place within this volume level will trigger a dead-time detector response. This action of the digitizer simulates the time during which this detector, busy at processing a particle, will not be able to process the next one. Moreover, one can simulate the case where data are accumulated into a buffer, which is written to a mass storage having a time access, during which no other data can be processed. In such a case, the dead time is not started after the first data, but once the buffer is full. This case can also be simulated in GATE.
To apply a dead-time to the volume_name (which has to be previously attached to a level of the system), the following commands can be used:
# ATTACHEMENT TO THE SYSTEM /gate/systems/system_name/system_level_name/attach volume_name .. .. # DEADTIME /gate/digitizer/Singles/insert deadtime /gate/digitizer/Singles/deadtime/setDeadTime 100000. ns /gate/digitizer/Singles/deadtime/setMode paralysable /gate/digitizer/Singles/deadtime/chooseDTVolume volume_name
The name system_name and its corresponding system_level_name do not exist and have to be chosen in the tables given in Users Guide V7.2:Defining a system.
In the second example, a dead time corresponding to a disk access of 1 µs for a memory buffer of 1 Mbyte is given. The setMode command specifies the behavior of the dead time during the disk access. If this mode is set to 0, the memory buffer is assumed to be a shared resource for the computer, and thus is not available during the disk writing. So, no data can fill the buffer during the disk access. On the other hand, in case of model 1, the buffer is immediately freed after being sent to the disk controller. Data are thus not rejected, unless the buffer is filled up again, before the disk access is finished. In such a case, the dead time module will be totally transparent (ie. will not reject any data), unless the counting rate is high enough to fill the buffer in a time lower than the disk access dead time.
# ATTACHEMENT TO THE SYSTEM /gate/systems/system_name/system_level_name/attach volume_name .. .. # DEADTIME /gate/digitizer/Singles/insert deadtime /gate/digitizer/Singles/deadtime/setDeadTime 1 mus /gate/digitizer/Singles/deadtime/setMode nonparalysable /gate/digitizer/Singles/deadtime/chooseDTVolume volume_name /gate/digitizer/Singles/deadtime/setBufferSize 1 MB /gate/digitizer/Singles/deadtime/setBufferMode 0
Multiple processor chains
The use of multiple processor chains makes the design of the digitizer and data output system extremely flexible. The manager for the pulse-processors is called the GatePulseProcessorChain, and has a messenger called the GatePulseProcessorChainMessenger. By default, all the digitizer components are stored in one processor-chain called digitizer/Singles. New processor chains can be created that specify the source of their data. For instance, the following sequence of commands will generate three outputs:
- Singles with no energy cut
- LESingles with a low-energy window
- HESingles with a high-energy window
For a standard PET (with BGO crystals), the components of the standard processor chain will consist in the following commands:
/gate/digitizer/Singles/insert adder /gate/digitizer/Singles/insert readout /gate/digitizer/Singles/readout/setDepth 1
To add the blurring filter to the "Single" branch:
/gate/digitizer/Singles/insert blurring /gate/digitizer/Singles/blurring/setResolution 0.26 /gate/digitizer/Singles/blurring/setEnergyOfReference 511. keV
The following commands create a low-energy chain branching from the output of "Singles" chain:
/gate/digitizer/name LESingles /gate/digitizer/insert singleChain /gate/digitizer/LESingles/setInputName Singles /gate/digitizer/LESingles/insert thresholder /gate/digitizer/LESingles/thresholder/setThreshold 50. keV /gate/digitizer/LESingles/insert upholder /gate/digitizer/LESingles/upholder/setUphold 350. keV
These next commands create a high-energy chain branching from the output of the "Singles" chain:
/gate/digitizer/name HESingles /gate/digitizer/insert singleChain /gate/digitizer/HESingles/setInputName Singles /gate/digitizer/HESingles/insert thresholder /gate/digitizer/HESingles/thresholder/setThreshold 350. keV /gate/digitizer/HESingles/insert upholder /gate/digitizer/HESingles/upholder/setUphold 650. keV
The coincidence sorter searches, into the singles list, for pairs of coincident singles. Whenever two or more singles are found within a coincidence window, these singles are grouped to form a Coincidence event. Two methods are possible to find coincident singles within GATE. In the first method, when a single is detected, it opens a new coincidence window, and search for a second single occurring during the length of the window. In this method, as long as the window opened by the first single is not closed, no other single can open its own coincidence window. In the second method, all singles open their own coincidence window, and a logical OR is made between all the individual signals to find coincidences. The two methods are available in GATE, and can lead to slightly different results, for a given window width. A comparison of the difference of these two behaviors in a real case is sketched in figure 8.5.
To exclude coincidence coming from the same particle that scattered from a block to an adjacent block, the proximity of the two blocks forming the coincidence event is tested. By default, the coincidence is valid only if the difference in the block numbers is greater or equal to two, but this value can be changed in GATE if needed.
Each Single emitted from a given source particle is stored with an event ID number, which uniquely identifies the decay from which the single is coming from. If two event ID numbers are not identical in a coincidence event, the event is defined as a Random coincidence.
An experimental method used to estimate the number of random coincidences consists of using a delayed coincidence window. By default, the coincidence window is opened when a particle is detected (i.e. when a Single is created). In this method, a second coincidence window is created in parallel to the normal coincidence window (which in this case is referred to as the prompt window). The second window (usually with the same width) is open, but is shifted in time. This shift should be long enough to ensure that two particles detected within it are coming from different decays. The resulting number of coincidences detected in this delayed window approximates the number of random events counted in the prompt window. GATE offers the possibility to specify an offset value, for the coincidence sorter, so that prompts and/or delayed coincidence lines can be simulated.
When more than two singles are found in coincidence, several type of behavior could be implemented. GATE allows to model 9 different rules that can be used in such a case. The list of rules along with their explanation are given in table 8.2, and a comparison of the effects of each processing rule for various cases of multiple coincidences is shown in figure 8.6. If no policy is specified, the default one used is: keepIfAllAreGoods.
|takeAllGoods||Each good pairs are considered.|
|takeWinnerOfGoods||Only the good pair with the highest energy is considered.|
|takeWinnerIfIsGood||If the pair with the highest energy is good, take it, otherwise, kill the event.|
|takeWinnerIfAllAreGoods||If all pairs are goods, take the one with the highest energy.|
|keepIfOnlyOneGood||If exactly one pair is good, keep the multicoincidence.|
|keepIfAnyIsGood||If at least one pair is good, keep the multicoincidence.|
|keepIfAllAreGoods||If all pairs are goods, keep the multicoincidence.|
|killAllIfMultipleGoods||If more than one pairs is good, the event is seen as a real "multiple" and thus, all events are killed.|
|killAll||No multiple coincidences are accepted, no matter how many good pairs are present.|
|Policy name||Case 1||Case 2||Case 3||Case 4|
|takeAllGoods||(1,2)||(1,2); (1,3); (2,3)||(1,2); (2,3)||(1,3); (2,3)|
To set up a coincidence window of 10 ns, the user should specify:
/gate/digitizer/Coincidences/setWindow 10. ns
To change the default value of the minimum sector difference for valid coincidences (the default value is 2), the command line should be used:
By default, the offset value is equal to 0, which corresponds to a prompt coincidence sorter. If a delayed coincidence sorter is to be simulated, with a 100 ns time shift for instance, the offset value should be set using the command:
/gate/digitizer/Coincidences/setOffset 100. ns
To specify the depth of the system hierarchy for which the coincidences have to be sorted, the following command should be used:
/gate/digitizer/Coincidences/setDepth <system's depth (1 by default)>
As explained in figure 8.5, there are two methods for building coincidences. The default one is the method 1. To switch to method 2, one should use:
So when set to false (by default) the method 1 is chosen, and when set to true, this is the method 2. Be aware that the method 2 is experimental and not validated at all, so potentially containing non-reported bugs.
Finally, the rule to apply in case of multiple coincidences is specified as follows:
The default multiple policy is keepIfAllAreGoods.
Multiple coincidence sorters
Multiple coincidence sorters can be used in GATE. To create a coincidence sorter, the sorter must be named and a location specified for the input data. In the example below, three new coincidence sorters are created:
- One with a very long coincidence window:
/gate/digitizer/name LongCoincidences /gate/digitizer/insert coincidenceSorter /gate/digitizer/LongCoincidences/setInputName Singles /gate/digitizer/LongCoincidences/setWindow 1000. ns
- One for low-energy singles
/gate/digitizer/name LECoincidences /gate/digitizer/insert coincidenceSorter /gate/digitizer/LECoincidences/setWindow 10. ns /gate/digitizer/LECoincidences/setInputName LESingles
- One for high-energy-singles
/gate/digitizer/name HECoincidences /gate/digitizer/insert coincidenceSorter /gate/digitizer/HECoincidences/setWindow 10. ns /gate/digitizer/HECoincidences/setInputName HESingles
A schematic view corresponding to this example is shown in figure 8.7.
Coincidence processing and filtering
Coincidence pulse processors
Once the coincidences are identified, further processing can be applied to mimic count losses that may occur because of the acquisition limitations, such as dead time. Count loss may also be due to the limited bandwidth of wires or buffer capacities of the I/O interface. The modelling of such effects within GATE is explained below. Moreover, for PET scanners using a delayed coincidence line, data coming from the two types of coincidences (ie. prompts and delayed) can be processed by a unique coincidence sorter. If so, the rate of a coincidence type can affect the rate of the other. For instance, a prompt coincidence can produce dead time which will hide a delayed coincidence. The prompt coincidence events can also saturate the bandwidth, so that the random events are partially hidden.
The modelling of such effects consists in grouping the two different coincidence types into a unique one, which is then processed by a unique filter.
A coincidence pulse processor is a structure that contains the list of coincidence sources onto which a set of filters will be applied, along with the list of filters themselves. The order of the list of coincidence may impact the repartition of the data loss between the prompt and the delay lines. For example, if the line of prompt coincidences has priority over the line of delayed coincidences, then the events of the latter have more risk to be rejected by a possible buffer overflow than those of the former. This kind of effects can be suppressed by specifying that, inside an event, all the coincidences arriving with the same time flag are merged in a random order.
To implement a coincidence pulse processor merging two coincidence lines into one, and apply an XXX module followed by another YYY module on the total data flow, one should use the following commands, assuming that the two coincidence lines named prompts and delayed are already defined:
/gate/digitizer/name myCoincChain /gate/digitizer/insert coincidenceChain /gate/digitizer/myCoincChain/addSource prompts /gate/digitizer/myCoincChain/addSource delayed /gate/digitizer/myCoincChain/insert XXX # set parameter of XXX.... /gate/digitizer/myCoincChain/insert YYY # set parameter of YYY....
To specify that two coincidences arriving with the same time flag have to be processed in random order, one should use the command:
Coincidence dead time
The dead time for coincidences works in the same way as that acting on the singles data flow. The only difference is that, for the single dead time, one can specify the hierarchical level to which the dead time is applied on (corresponding to the separation of detectors and electronic modules), while in the coincidence dead time, the possibility to simulate separate coincidence units (which may exist) is not implemented. Apart from this limitation, the command lines for coincidence dead time are identical to the ones for singles dead time, as described in #Pile-up. When more than one coincidence can occur for a unique GEANT4 event (if more than one coincidence line are added to the coincidence pulse processor, or if multiple coincidences are processed as many coincidences pairs), then the user can specify that the whole event is kept or rejected, depending on the arrival time of the first coincidence. To do so, one should use the command line:
The buffer module for affecting coincidences uses exactly the same command lines and functionalities as the ones used for single pulse lists, and described in section #Local efficiency.
Multiple coincidence removal
If the multiple coincidences are kept and not splitted into pairs (ie. if any of the keepXXX multiple coincidence policy is used), the multicoincidences could participate to dataflow occupancy, but could not be written to the disk. Unless otherwise specified, any multicoincidence is then cleared from data just before the disk writing. If needed, this clearing could be performed at any former coincidence processing step, by inserting the multipleKiller module at the required level. This module has no parameter and just kill the multicoincidence events. Multiple coincidences split into many pairs are not affected by this module and cannot be distinguished from the normal "simple" coincidences. To insert a multipleKiller, one has to use the syntax:
Example of a digitizer setting
Here, the digitizer section of a GATE macro file is analyzed line by line. The readout scheme produced by this macro, which is commented on below, is illustrated in Figure 8.8.
1 # A D D E R 2 /gate/digitizer/Singles/insert adder 3 4 # R E A D O U T 5 /gate/digitizer/Singles/insert readout 6 /gate/digitizer/Singles/readout/setDepth 7 8 # E N E R G Y B L U R R I N G 9 /gate/digitizer/Singles/insert blurring 10 /gate/digitizer/Singles/blurring/setResolution 0.26 11 /gate/digitizer/Singles/blurring/setEnergyOfReference 511. keV 12 13 # L O W E N E R G Y C U T 14 /gate/digitizer/Singles/insert thresholder 15 /gate/digitizer/Singles/thresholder/setThreshold 50. keV 16 17 /gate/digitizer/name cutLowSingles 18 /gate/digitizer/insert singleChain 19 /gate/digitizer/cutLowSingles/setInputName Singles 20 21 # N O I S E 22 23 /gate/distributions/name energy_distrib 24 /gate/distributions/insert Gaussian 25 /gate/distributions/energy_distrib/setMean 450 keV 26 /gate/distributions/energy_distrib/setSigma 30 keV 27 28 /gate/distributions/name dt_distrib 29 /gate/distributions/insert Exponential 30 /gate/distributions/dt_distrib/setLambda 7.57 mus 31 32 /gate/digitizer/cutLowSingles/insert noise 33 /gate/digitizer/cutLowSingles/noise setDeltaTDistributions dt_distrib 34 /gate/digitizer/cutLowSingles/noise setEnergyDistributions energy_distrib 35 36 # D E A D T I M E 37 /gate/digitizer/cutLowSingles/insert deadtime 38 /gate/digitizer/cutLowSingles/deadtime/setDeadTime 2.2 mus 39 /gate/digitizer/cutLowSingles/deadtime/setMode paralysable 40 /gate/digitizer/cutLowSingles/deadtime/chooseDTVolume module 41 42 # H I G H E N E R G Y C U T 43 /gate/digitizer/name cutSingles 44 /gate/digitizer/insert singleChain 45 /gate/digitizer/cutSingles/setInputName cutLowSingles 46 /gate/digitizer/cutSingles/name highThresh 47 /gate/digitizer/cutSingles/insert thresholder 48 /gate/digitizer/cutSingles/highThresh/setThreshold 350. keV 49 /gate/digitizer/cutSingles/insert upholder 50 /gate/digitizer/cutSingles/upholder/setUphold 700. keV 51 52 /gate/digitizer/cutSingles/name deadtime_cassette 53 /gate/digitizer/cutSingles/insert deadtime 54 /gate/digitizer/cutSingles/deadtime_cassette/setDeadTime 0.55 mus 55 /gate/digitizer/cutSingles/deadtime_cassette/setMode nonparalysable 56 /gate/digitizer/cutSingles/deadtime_cassette/chooseDTVolume cassette 57 /gate/digitizer/cutSingles/name deadtime_group 58 /gate/digitizer/cutSingles/insert deadtime 59 /gate/digitizer/cutSingles/deadtime_group/setDeadTime 0.250 mus 60 /gate/digitizer/cutSingles/deadtime_group/setMode nonparalysable 61 /gate/digitizer/cutSingles/deadtime_group/chooseDTVolume group 62 63 64 # C O I N C I S O R T E R 65 65 /gate/digitizer/Coincidences/setInputName cutSingles 66 /gate/digitizer/Coincidences/setOffset 0. ns 67 /gate/digitizer/Coincidences/setWindow 24. ns 68 /gate/digitizer/Coincidences/minSectorDifference 3 69 70 /gate/digitizer/name delayedCoincidences 71 /gate/digitizer/insert coincidenceSorter 72 /gate/digitizer/delayedCoincidences/setInputName cutSingles 73 /gate/digitizer/delayedCoincidences/setOffset 100. ns 74 /gate/digitizer/delayedCoincidences/setWindow 24. ns 75 /gate/digitizer/delayedCoincidences/minSectorDifference 3 76 77 /gate/digitizer/name finalCoinc 78 /gate/digitizer/insert coincidenceChain 79 /gate/digitizer/finalCoinc/addInputName delay 80 /gate/digitizer/finalCoinc/addInputName Coincidences 81 /gate/digitizer/finalCoinc/usePriority true 82 /gate/digitizer/finalCoinc/insert deadtime 83 /gate/digitizer/finalCoinc/deadtime/setDeadTime 60 ns 84 /gate/digitizer/finalCoinc/deadtime/setMode nonparalysable 85 /gate/digitizer/finalCoinc/deadtime/conserveAllEvent true 86 /gate/digitizer/finalCoinc/insert buffer 87 /gate/digitizer/finalCoinc/buffer/setBufferSize 32 B 88 /gate/digitizer/finalCoinc/buffer/setReadFrequency 14.45 MHz 89 /gate/digitizer/finalCoinc/buffer/setMode 0
Lines 1 to 15: The branch named "Singles" contains the result of applying the adder, readout, blurring, and threshold (50 keV) modules.
Lines 17 to 20: A new branch (line 18) is defined, named "cutLowSingles" (line 17), which follows the "Singles" branch in terms of data flow (line 19).
Lines 21 to 35: Two distributions are created, which will be used for defining a background noise. The first distributions, named energy_distribution (line 23) is a Gaussian centered on 450 keV and of 30 keV standard deviation, while the second one is an exponential distribution with a power of 7.57 \mu s. These two distributions are used to add noise. The energy distribution of this source of noise is Gaussian, whileThe exponential distribution represents the distribution of time interval between two consecutive noise events (lines 32-34).
Lines 37 to 40: A paralysable (line 39) dead time of 2.2 \mu s is applied on the resulting signal+noise events.
Lines 43 to 62: Another branch (line 44) named "cutSingles" (line 43) is defined. This branch contains a subset of the "cutLowSingles" branch (line 45) (after dead-time has been applied), composed of those events which pass through the 350 keV/700 keV threshold/uphold window (lines 46-50). In addition, the events tallied in this branch must pass the two dead-time cuts (lines 52 to 61) after the energy window cut.
Lines 65 to 68: The "default" coincidence branch consists of data taken from the output of the high threshold and two dead-time cuts ("cutSingles") (line 65). At this point, a 24 ns window with no delay is defined for this coincidence sorter.
Lines 70 to 75: A second coincidence branch is defined (line 71), which is named "delayedCoincidences". This branch takes its data from the same output ("cutSingles"), but is defined by a delayed coincidence window of 24 ns, and a 100 ns delay (line 73).
Lines 77 to 89: The delayed and the prompts coincidence lines are grouped (lines 79-80). Between two coincidences coming from these two lines and occuring within a given event, the priority is set to the delayed line, since it is inserted before the prompt line, and the priority is used (line 81). A non-paralysable dead time of 60 ns is applied on the delayed+prompt coincidences (lines 82-85). If more than one coincidence occur inside a given event, the dead time can kill all of them or none of them, depending on the arrival time of the first one. As a consequence, if a delay coincidence is immediately followed by a prompt coincidence due to the same photon, then, the former will not hide the latter (line 85). Finally, a memory buffer of 32 coincidences, read at a frequency of 14.45 MHz, in an event-by-event basis (line 89) is applied to the delayed+prompt sum (lines 86-89).
In GATE standard operation mode, primary particles are generated by the source manager, and then propagated through the attenuating geometry before generating hits in the detectors, which feed into the digitizer chain. While this operation mode is suited for conventional simulations, it is inefficient when trying to optimize the parameters of the digitizer chain. In this case, the user needs to compare the results obtained for different sets of digitizer parameters that are based upon the same series of hits. Thus, repeating the particle generation and propagation stages of a simulation is unnecessary for tuning the digitizer setting.
For this specific situation, GATE offers an operation mode dedicated to digitizer optimization, known as DigiGATE. In this mode, hits are no longer generated: instead, they are read from a hit data-file (obtained from an initial GATE run) and are fed directly into the digitizer chain. By bypassing the generation and propagation stages, the computation speed is significantly reduced, thus allowing the user to compare various sets of digitizer parameters quickly, and optimize the model of the detection electronics. DigiGATE is further explained in chapter 13.
Angular Response Functions to speed-up planar or SPECT simulations
The ARF is a function of the incident photon direction and energy and represents the probability that a photon will either interact with or pass through the collimator, and be detected at the intersection of the photon direction vector and the detection plane in an energy window of interest. The use of ARF can significantly speed up planar or SPECT simulations. The use of this functionality involves 3 steps.
Calculation of the data needed to derive the ARF tables
In this step, the data needed to generate the ARF tables are computed from a rectangular source located at the center of FOV. The SPECT head is duplicated twice and located at roughly 30 cm from the axial axis.
The command needed to compute the ARF data is:
The ARF data are stored in ROOT format as specified by the GATE command output:
By default the maximum size of a ROOT file is 1.8 Gbytes. Once the file has reached this size, ROOT automatically closes it and opens a new file name testARFdata_1.root. When this file reaches 1.8 Gb, it is closed and a new file testARFdata_2.root is created etc. A template macro file is provided in https://github.com/OpenGATE/GateContrib/blob/master/imaging/ARF/generateARFdata.mac which illustrates the use of the commands listed before.
Computation of the ARF tables from the simulated data
Once the required data are stored in ROOT files, the ARF tables can be calculated and stored in a binary file:
The digitizer parameters needed for the computation of the ARF table are defined by:
/gate/systems/SPECThead/ARFTables/setEnergyDepositionThreshHold 328. keV /gate/systems/SPECThead/ARFTables/setEnergyDepositionUpHold 400. keV /gate/systems/SPECThead/ARFTables/setEnergyResolution 0.10 /gate/systems/SPECThead/ARFTables/setEnergyOfReference 140. keV
In this example, we shot photons with 364.5 keV as kinetic energy. We chose an energy resolution of 10% @ 140 keV and the energy window was set to [328-400] keV. The simulated energy resolution at an energy Edep will be calculated by:
where Edep is the photon deposited energy.
If we want to discard photons which deposit less than 130 keV, we may use:
/gate/systems/SPECThead/setEnergyDepositionThreshHold 130. keV
The ARF tables depend strongly on the distance from the detector to the source used in the previous step. The detector plane is set to be the half-middle plan of the detector part of the SPECT head. In our example, the translation of the SPECT head was 34.5 cm along the X direction (radial axis), the detector was 2 cm wide along X and its center was located at x = 1.5 cm with respect to the SPECThead frame. This is what we call the detector plane (x = 1.5 cm) so the distance from the source to the detector plane is 34.5 + 1.5 = 36 cm.
# DISTANCE FROM SOURCE TO DETECTOR PLANE TAKEN TO BE THE PLANE HALF-WAY THROUGH THE CRYSTAL RESPECTIVELY TO THE SPECTHEAD FRAME : here it is 34.5 cm + 1.5 cm /gate/systems/SPECThead/ARFTables/setDistanceFromSourceToDetector 36 cm
The tables are then computed from a text file which contains information regarding the incident photons called ARFData.txt which is provided in https://github.com/OpenGATE/GateContrib/tree/master/imaging/ARF
# NOW WE ARE READY TO COMPUTE THE ARF TABLES /gate/systems/SPECThead/ARFTables/ComputeTablesFromEnergyWindows ARFData.txt
The text file reads like this:
# this file contains all the energy windows computed during first step # with their associated root files # it has to be formatted the following way # [Emin,Emax] is the energy window of the incident photons # the Base FileName is the the name of the root files name.root, name_1.root name_2.root ... # the number of these files has to be given as the last parameter # # enter the data for each energy window # Incident Energy Window: Emin - Emax (keV) | Root FileName | total file number 0. 365. test1head 20
Here we have only one incident energy window for which we want to compute the corresponding ARF tables. The data for this window are stored inside 20 files whose base file name is test1head. These ARF data files were generated from the first step and were stored under the names of test1head.root, test1head_1.root ... test1head_19.root.
Finally the computed tables are stored to a binary file:
/gate/systems/SPECThead/ARFTables/list # SAVE ARF TABLES TO A BINARY FILE FOR PRODUCTION USE /gate/systems/SPECThead/ARFTables/saveARFTablesToBinaryFile ARFSPECTBench.bin
Use of the ARF tables
The command to tell GATE to use ARF tables is:
The ARF sensitive detector is attached to the SPECThead:
These tables are loaded from binary files with:
Multi-system approaches: how to use more than one system in one simuation set-up ?
Singles arriving from different systems request different treatment in the digitizer. So we have to use multiple digitizer chains and to separate between theses singles according to their systems.
The systemFilter module separates between the singles coming from systems. This module have one parameter which is the name of the system.
/gate/digitizer/SingleChain/insert systemFilter /gate/digitizer/SingleChain/systemFilter/selectSystem SystemName
SingleChain is the singles chain, Singles by default, and SystemName is the name of the selected system.
Suppose that we have two systems with the names “cylindricalPET” and “Scanner_1”, so to select singles in cylindricalPET system we use:
/gate/digitizer/Singles/insert systemFilter /gate/digitizer/Singles/systemFilter/selectSystem cylindricalPET
Note we didn't insert a singles chain because we have the default chain “Singles”, on the other side for “ Scanner_1” we to insert a new singles chain “Singles_S1 ”:
/gate/digitizer/name Singles_S1 /gate/digitizer/insert singleChain
Then we insert the system filter.
/gate/digitizer/Singles_S1/insert systemFilter /gate/digitizer/Singles_S1/systemFilter/selectSystem Scanner_1
How to manage the coincidence sorter with more than one system: the Tri Coincidence Sorter approach
The aim of this module is to obtain the coincidence between coincidence pulses and singles of another singles chain (between TEP camera and scanner for example). In this module we search the singles, of the concerned singles chain, which are in coincidence with the coincidence pulses according to a time window. In fact, this module, from the point of view of the code, is coincidence pulses processor. So we have a coincidence chain as input with a singles chain. We have also to define a time window to search the coincident coincidence-singles within this window. We test the time difference between the average time of the tow singles of the coincidence pulse and the time of every single of the singles chain in question. We have as output of this module two trees of ROOT: one tree contain the coincidences which have at first one coincident single with every one of them. The second tree contain the coincident singles and it is generated automatically with name of coincidence tree+”CSingles”. For example if we call the coincidence “triCoinc”, so the name of the singles tree will be “ triCoincCSingles”. This singles tree contain the same branches as any singles tree with an additional branch named “triCID” from (tri coincidence ID) and it has the same value for all singles which are in coincidence with one coincidence pulse.
In this module we store the singles event by event in a singles buffer that have a semi-constant size that the user can adjust. When we have a coincidence pulse we compare between the average time of this coincidence pulse and the time of each single pulse in the buffer. When we have coincident singles with the coincidence pulse, we store them in two trees as mentioned above.
Define the classical coincidence sorter applied on the cylindrical PET system:
/gate/digitizer/Coincidences/setWindow 30. ns
Define now a "coincidenceChain" where you will plug the first coincidence sorter (named 'Coincidences' in that case):
/gate/digitizer/name TriCoinc /gate/digitizer/insert coincidenceChain /gate/digitizer/TriCoinc/addInputName Coincidences
Finally, we call the 'triCoincProcessor' module and we plug on it the second system which define in that case by the 'Singles_S1' chain:
/gate/digitizer/TriCoinc/insert triCoincProcessor /gate/digitizer/TriCoinc/triCoincProcessor/setSinglesPulseListName Singles_S1 /gate/digitizer/TriCoinc/triCoincProcessor/setWindow 15 ns /gate/digitizer/TriCoinc/triCoincProcessor/setSinglesBufferSize 40